The roadmap for harmonisation of digital health across Europe is underway. The European Health Data Space (EHDS) intends to provide a trusted and secure cross border digital infrastructure called MyHealth@EU that will connect Member States and will allow individuals to share their health data via access points established by Member States. What is its significance and what are the challenges? Could this initiative be a “gamechanger” for how healthcare is delivered in Europe and how health research is carried out?